Adrian Thrasher is a Professor in Paediatric Immunology and Wellcome Trust SRF at the Infection, Immunity, Inflammation and Physiological Medicine UCL Institute of Child Health at London.
He studied medicine in St George's Hospital Medical School at London and recieved his MBBS in 1986. He got his Phd in Applied Genetics at University College London in 1989.
Professor Thrasher is the head of IIIP academic programme which aims to deliver world class interdisciplinary research for children with infectious, immunological and inflammatory disease, children with life threatening respiratory disease, children in pain and critically ill children on intensive care.
The main research interest of professor's Thrasher is focused on conducting trials of somatic gene therapy for various forms of PID including SCID-X1, CGD, ADA-SCID, and WAS. Other research interests include the pathophysiology of primary immunodeficiency syndromes especially WAS, the actin cytoskeleton in haematopoietic cells (with Dr Siobhan Burns), the development of somatic gene therapy (with Professor Bobby Gaspar, Professor Christine Kinnon, Dr Waseem Qasim, and for ocular disease with Professor Robin Ali), and thymus transplantation (with Dr Graham Davies).
Bobby Gaspar is a physician/scientist working in paediatric immunology at the Institute of Child Health (ICH) and Great Ormond Street London. He initially trained in paediatrics and then became interested in primary immunodeficiencies at an early stage in his career and undertook a PhD at the Molecular Immunology Unit at ICH. From there he has continued his academic and clinical career.
His interests are in many different aspects of primary immunodeficiency including understanding the molecular and cellular defects and disease pathogenesis, bone marrow transplantation for severe immunodeficiencies and the development of gene and cell therapy for these conditions. Over the last decade, his team have conducted clinical trials that have shown that gene therapy can successfully correct the immune defect in specific immunodeficiency conditions. He is also leading UK and European initiatives for newborn screening for severe combined immunodeficiency.
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